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American Journal of Epidemiology Vol. 130, No. 6: 1152-1158
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

CHRONIC LYMPHOCYTIC LEUKEMIA IN RELATION TO CHEMICAL EXPOSURES

KATHLEEN E. MALONE1,2,, THOMAS D. KOEPSELL1, JANET R. DALING1,2, NOEL S. WEISS1,2, PETER D. MORRIS3, JOHN W. TAYLOR4, G. MARIE SWANSON5 and J. LYNN LYON6

1Department of Epidemiology, University of Washington Seattle, WA
2Fred Hutchinson Cancer Research Center Seattle, WA
3North Carolina Department of Human Resources, Division of Health Services Raleigh, NC
4Formerly with the Department of Epidemiology, University of Washington now in private practice
5Division of Epidemiology, Michigan Cancer Foundation Detroit, MI
6Division of Epidemiology, Department of Family and Community Medicine, University of Utah Medical Center Salt Lake City, UT.

Reprint requests to Kathleen E. Malone, Fred Hutchinson Cancer Research Center, 1124 Columbia Street #MP-381, Seattle, WA 98104

As part of a population-based case-control study carried out in four areas of the United States, 427 cases of chronic lymphocytic leukemia diagnosed between July 1, 1977, and December 31, 1981, and 1,683 controls were interviewed regarding their history of chemical exposure. Respondents were asked if they had ever been "highly exposed" at home, at work, or elsewhere to one or more of a list of chemicals or to any other such substances not on the list. These chemicals were categorized into 20 exposure groups based on chemical composition. Odds ratios were calculated adjusting for age, sex, race, education level, and geographic location by means of unconditional logistic regression. Increased risks were associated with reported past exposure to acid-containing chemicals, "other caustic substances," aliphatic hydrocarbons, and chlorinated hydrocarbons. Because of the large number of exposures investigated in this study, and because of the relatively imprecise means the authors had to assess exposure, further research is needed to verify these findings.

environmental exposure; leukemia; lymphocytic; occupational diseases


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