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American Journal of Epidemiology Vol. 141, No. 3: 218-224
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Tuberculosis in Relation to a History of Peptic Ulcer Disease and Treatment of Gastric Hyperacidity

Susan E. Buskin1,2,, Noel S. Weiss2,3, James L. Gale2,4 and Charles M. Nolan1,2,5

1Seattle-King County Department of Public Health Seattle, WA
2Department of Epidemiology, University of Washington Seattle, WA
3Fred Hutchinson Cancer Research Center Seattle, WA
4Kittitas County Department of Public Health Ellensburg, WA
5School of Medicine, University of Washington Seattle, WA

Reprint requests to Dr. Susan Buskin, 400 Yesler Building, 3rd Floor, Seattle, WA 98104

Previous studies described an excess of tuberculosis among persons with a history of partial gastrectomy for the treatment of peptic ulcer disease. It is unknown if any contemporary therapies for peptic ulcer disease, such as histamine type 2 antagonists and antacids, are also associated with elevated risks of tuberculosis. A case-control study was conducted during 1988–1990 In the Seattle-King County Tuberculosis Clinic to address these questions. Self-administered questionnaires were completed by 135 cases with active tuberculosis and 380 controls. A history of daily antacid use was reported by 11 cases (8%) and 23 controls (6%), corresponding to an adjusted odds ratio of 0.9 (95% confidence interval 0.4–2.0). A history of daily histamine type 2 antagonist use was reported by nine cases (7%) and 18 controls (5%) with an adjusted odds ratio of 0.8 (95% confidence interval 0.3–2.1). Our results, while based on a relatively small number of subjects, suggest that treatment for peptic ulcer disease has no influence on the occurrence of tuberculosis.

antacids; gastrectomy; histamine antagonists; peptic ulcer; tuberculosis


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