American Journal of Epidemiology Vol. 141, No. 6: 523-530
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Case-Control Study of Bladder Cancer and Arsenic in Drinking Water
1Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California Berkeley, CA
2Current affiliation: Institute of Environmental Science and Research Porirua, New Zealand
3Environmental Epidemiology Branch, National Cancer Institute Bethesda, MD
Reprint requests to Dr. Michael Bates, Institute of Environmental Science and Research, P.O. Box 50-348, Porirua, New Zealand
Mortality from several cancers, including bladder cancer, is elevated in a Taiwanese population exposed to high levels of arsenic in drinking water. Data from the Utah respondents to the National Bladder Cancer Study conducted in 1978 were used to evaluate these associations in a US population exposed to measurable, but much lower, levels of drinking water arsenic. Two indices of cumulative arsenic exposure were used, one representing total cumulative exposure (index 1) and the other, intake concentration (index 2). Overall, there was no association of bladder cancer with either measure; however, among smokers, but not among nonsmokers, positive trends in risk were found for exposures estimated for decade-long time periods, especially in the 30- to 39-year period prior to diagnosis. Exposures were in the range 0.5–160 µg/liter (mean, 5.0 µg/liter). The data raise the possibility that smoking potentiates the effect of arsenic on risk of bladder cancer. However, the risk estimates obtained are much higher than predicted on the basis of the results of the Talwanese studies, raising concerns about bias or the role of chance. Confirmatory studies are needed. Am J Epidemiol 1995;141:523–30.
arsenic; bladder neoplasms; smoking; water pollutants; water supply
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Marshall, C. Ferreccio, Y. Yuan, M. N. Bates, C. Steinmaus, S. Selvin, J. Liaw, and A. H. Smith Fifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water J Natl Cancer Inst, June 20, 2007; 99(12): 920 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J MARSIT, M. R KARAGAS, A. SCHNED, and K. T KELSEY Carcinogen exposure and epigenetic silencing in bladder cancer. Ann. N.Y. Acad. Sci., September 1, 2006; 1076: 810 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ding, J. Li, C. Xue, K. Wu, W. Ouyang, D. Zhang, Y. Yan, and C. Huang Cyclooxygenase-2 Induction by Arsenite Is through a Nuclear Factor of Activated T-cell-dependent Pathway and Plays an Antiapoptotic Role in Beas-2B Cells J. Biol. Chem., August 25, 2006; 281(34): 24405 - 24413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D Ayotte, D. Baris, K. P Cantor, J. Colt, G. R Robinson Jr, J. H Lubin, M. Karagas, R. N Hoover, J. F Fraumeni Jr, and D. T Silverman Bladder cancer mortality and private well use in New England: an ecological study J. Epidemiol. Community Health, February 1, 2006; 60(2): 168 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Marsit, M. R. Karagas, H. Danaee, M. Liu, A. Andrew, A. Schned, H. H. Nelson, and K. T. Kelsey Carcinogen exposure and gene promoter hypermethylation in bladder cancer Carcinogenesis, January 1, 2006; 27(1): 112 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Michaud, M. E. Wright, K. P. Cantor, P. R. Taylor, J. Virtamo, and D. Albanes Arsenic Concentrations in Prediagnostic Toenails and the Risk of Bladder Cancer in a Cohort Study of Male Smokers Am. J. Epidemiol., November 1, 2004; 160(9): 853 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Bates, O. A. Rey, M. L. Biggs, C. Hopenhayn, L. E. Moore, D. Kalman, C. Steinmaus, and A. H. Smith Case-Control Study of Bladder Cancer and Exposure to Arsenic in Argentina Am. J. Epidemiol., February 15, 2004; 159(4): 381 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Steinmaus, Y. Yuan, M. N. Bates, and A. H. Smith Case-Control Study of Bladder Cancer and Drinking Water Arsenic in the Western United States Am. J. Epidemiol., December 15, 2003; 158(12): 1193 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boffetta and F. Nyberg Contribution of environmental factors to cancer risk Br. Med. Bull., December 1, 2003; 68(1): 71 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. O. Abernathy, D. J. Thomas, and R. L. Calderon Health Effects and Risk Assessment of Arsenic J. Nutr., May 1, 2003; 133(5): 1536S - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Karagas, T. A. Stukel, J. S. Morris, T. D. Tosteson, J. E. Weiss, S. K. Spencer, and E. R. Greenberg Skin Cancer Risk in Relation to Toenail Arsenic Concentrations in a US Population-based Case-Control Study Am. J. Epidemiol., March 15, 2001; 153(6): 559 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Chiou, S.-T. Chiou, Y.-H. Hsu, Y.-L. Chou, C.-H. Tseng, M.-L. Wei, and C.-J. Chen Incidence of Transitional Cell Carcinoma and Arsenic in Drinking Water: A Follow-up Study of 8,102 Residents in an Arseniasis-endemic Area in Northeastern Taiwan Am. J. Epidemiol., March 1, 2001; 153(5): 411 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Cantor Invited Commentary: Arsenic and Cancer of the Urinary Tract Am. J. Epidemiol., March 1, 2001; 153(5): 419 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stoica, E. Pentecost, and M. B. Martin Effects of Arsenite on Estrogen Receptor-{alpha} Expression and Activity in MCF-7 Breast Cancer Cells Endocrinology, October 1, 2000; 141(10): 3595 - 3602. [Abstract] [Full Text] [PDF]
|
|