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Am J Epidemiol 2004; 159:702-706.
Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health


ORIGINAL CONTRIBUTIONS

A Modified Poisson Regression Approach to Prospective Studies with Binary Data

Guangyong Zou1,2 

1 Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada.
2 Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.

Relative risk is usually the parameter of interest in epidemiologic and medical studies. In this paper, the author proposes a modified Poisson regression approach (i.e., Poisson regression with a robust error variance) to estimate this effect measure directly. A simple 2-by-2 table is used to justify the validity of this approach. Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100. The method is illustrated with two data sets.

clinical trials; cohort studies; logistic regression; Mantel-Haenszel; odds ratio; relative risk

Abbreviations: Abbreviations: CI, confidence interval; RR, relative risk.


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