Am J Epidemiol 2004; 159:922-924.
Copyright © 2004 by the Johns
Hopkins Bloomberg School of Public Health
PRACTICE OF EPIDEMIOLOGY |
Invited Commentary: Birth CertificatesA Best Control Scenario?
1 Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
2 University of Minnesota Cancer Center, Minneapolis, MN.
3 Department of Epidemiology, University of North Carolina, Chapel Hill, NC.
4 Childrens Hospital of Philadelphia, Philadelphia, PA.
Received for publication January 16, 2004; accepted for publication February 12, 2004.
Abbreviations: Abbreviation: RDD, random digit dialing.
| The first 10% of the full text of this article appears below. |
| INTRODUCTION |
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The majority of conditions that affect children under the age of 15 years (e.g., birth defects, diabetes, cancer) are sufficiently rare to warrant the case-control study approach. Furthermore, most pediatric studies require enrollment from multiple centers, registries, or hospitals to gain a sufficient sample size and thus can span large geographic areas. While selection of cases is usually straightforward, special care must be given to selection of controls to ensure that they represent the underlying population from which the cases arose. As Wacholder et al. (13) nicely described in a 1992 series of articles addressing control selection issues, an underlying cohort or study base can be primary or secondary. The primary base is the hallmark of a population-based case-control study in which all cases in a defined population are ascertained both geographically and temporally.
| RANDOM DIGIT DIALING |
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| ALTERNATIVE CONTROL GROUPS |
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Representativeness
Feasibility in tracing
Potential for expansion nationwide
| ACKNOWLEDGMENTS |
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