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American Journal of Epidemiology 2005 161(1):101-102; doi:10.1093/aje/kwi009
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Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health

LETTERS TO THE EDITOR

RE: "CANCER INCIDENCE AMONG PESTICIDE APPLICATORS EXPOSED TO ALACHLOR IN THE AGRICULTURAL HEALTH STUDY"

Charles Poole1, Mark Cullen2, Richard Irons3 and John Acquavella4

1 Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599-7435
2 Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, CT 06510
3 Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, Denver, CO 80262
4 Monsanto Company, St. Louis, MO 63167

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In a recent Journal article, Lee et al. concluded, "Our findings suggest a possible association between alachlor application and incidence of lymphohematopoietic cancers among applicators in the Agricultural Health Study" (1, p. 373). This interpretation, based on p values of 0.02 and 0.03 from trend analyses of unweighted and intensity-weighted alachlor use days, requires qualification in several ways. We describe two . . . [Full Text of this Article]


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