American Journal of Epidemiology Vol. 154, No. 6 : 544-556
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Cancer Incidence in New York State Acquired Immunodeficiency Syndrome Patients
1 New York State Department of Health, Bureau of HIV/AIDS Epidemiology, Albany, NY.
2 New York State Department of Health, Bureau of Chronic Disease Epidemiology and Surveillance, Albany, NY.
3 New York City Department of Health, Office of AIDS Surveillance, New York, NY.
To identify cancers that occur at higher rates in acquired immunodeficiency syndrome (AIDS) patients, the cancer experience of New York State (NYS) AIDS patients aged 15–69 years who were diagnosed between 1981 and 1994 was compared with that of the NYS general population. Sex and HIV risk group-specific standardized incidence ratios (SIRs), post-AIDS relative risks, and trends of relative risks were calculated to determine cancer risk. Among non-AIDS-related cancers, elevated SIRs were found for Hodgkin's disease (male, 8.0; female, 6.4; heterosexually infected males, 31.3); cancer of the rectum, rectosigmoid, and anus (male, 3.3; female, 3.0); trachea, bronchus, and lung (male, 3.3; female, 7.5); and brain and central nervous system (male, 3.1; female, 3.4; heterosexually infected females, 23.8) cancers. Moreover, significant trends of increasing relative risks from the pre-AIDS to the post-AIDS period were found for cancers of the rectum, rectosigmoid, and anus; trachea, bronchus, and lung; skin; and connective tissues (all sites, p < 0.05) among males. For AIDS-related cancers in women, invasive cervical cancer had an overall SIR of 9.1 (95% confidence interval: 6.9, 10.8) and a post-AIDS relative risk of 6.5 (95% confidence interval: 4.1, 9.7). This population-based registry linkage analysis evaluates cancer risk in AIDS patients by sex and risk factors and adds evidence that HIV-associated immunosuppression increases the risks of specific types of cancer.
acquired immunodeficiency syndrome; HIV; lymphoma; AIDS-related; lung neoplasms; registries; risk factors
Abbreviations: AIDS, acquired immunodeficiency syndrome; CNS, central nervous system; HIV, human immunodeficiency virus; IDU, injection drug user; MSM, men who have sex with men; NHL, non-Hodgkin's lymphoma; NYS, New York State; RR, relative risk; SIR, standardized incidence ratio
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Patel, D. L. Hanson, P. S. Sullivan, R. M. Novak, A. C. Moorman, T. C. Tong, S. D. Holmberg, J. T. Brooks, and for the Adult and Adolescent Spectrum of Disease P Incidence of Types of Cancer among HIV-Infected Persons Compared with the General Population in the United States, 1992-2003 Ann Intern Med, May 20, 2008; 148(10): 728 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Nam, M. Terabe, M.-J. Kang, H. Chae, N. Voong, Y.-a. Yang, A. Laurence, A. Michalowska, M. Mamura, S. Lonning, et al. Transforming Growth Factor {beta} Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17 Cancer Res., May 15, 2008; 68(10): 3915 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sutcliffe, E. Giovannucci, C. A. Gaydos, R. P. Viscidi, F. J. Jenkins, J. M. Zenilman, L. P. Jacobson, A. M. De Marzo, W. C. Willett, and E. A. Platz Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1573 - 1580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Hessol, S. Pipkin, S. Schwarcz, R. D. Cress, P. Bacchetti, and S. Scheer The Impact of Highly Active Antiretroviral Therapy on Non-AIDS-Defining Cancers among Adults with AIDS Am. J. Epidemiol., May 15, 2007; 165(10): 1143 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Philippe, C. Sarkis, M. Barkats, H. Mammeri, C. Ladroue, C. Petit, J. Mallet, and C. Serguera Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo PNAS, November 21, 2006; 103(47): 17684 - 17689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Cadranel, D Garfield, A Lavole, M Wislez, B Milleron, and C Mayaud Lung cancer in HIV infected patients: facts, questions and challenges. Thorax, November 1, 2006; 61(11): 1000 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Bini, J. Park, and F. Francois Use of Flexible Sigmoidoscopy to Screen for Colorectal Cancer in HIV-Infected Patients 50 Years of Age and Older. Arch Intern Med, August 14, 2006; 166(15): 1626 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Stathopoulos, Z. Zhu, M. B. Everhart, I. Kalomenidis, W. E. Lawson, S. Bilaceroglu, T. E. Peterson, D. Mitchell, F. E. Yull, R. W. Light, et al. Nuclear Factor-{kappa}B Affects Tumor Progression in a Mouse Model of Malignant Pleural Effusion Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 142 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Cheung, L. Pantanowitz, and B. J. Dezube AIDS-Related Malignancies: Emerging Challenges in the Era of Highly Active Antiretroviral Therapy Oncologist, June 1, 2005; 10(6): 412 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herida, M. Mary-Krause, R. Kaphan, J. Cadranel, I. Poizot-Martin, C. Rabaud, N. Plaisance, H. Tissot-Dupont, F. Boue, J.-M. Lang, et al. Incidence of Non-AIDS-Defining Cancers Before and During the Highly Active Antiretroviral Therapy Era in a Cohort of Human Immunodeficiency Virus-Infected Patients J. Clin. Oncol., September 15, 2003; 21(18): 3447 - 3453. [Abstract] [Full Text] [PDF]
|
|