American Journal of Epidemiology Vol. 155, No. 5 : 472-477
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration
1 Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
2 Research and Development Unit, Social Insurance Institution, Helsinki, Finland.
3 Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center, Helsinki, Finland.
4 Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.
The lignan enterolactone, a phytoestrogen, may protect against hormone-dependent cancers and cardiovascular diseases. It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether serum enterolactone concentration is affected by previous use of oral antimicrobials. Enterolactone was measured by time-resolved fluoroimmunoassay in 2,753 Finnish men and women aged 25–64 years who participated in a cross-sectional national survey in 1997. Background information was collected by self-administered questionnaire, and data on antimicrobial treatment were gathered from the nationwide prescription database of the Social Insurance Institution. Serum enterolactone concentration was significantly lower in those who had used oral antimicrobials up to 12–16 months before serum sampling than in nonusers (16.4 vs. 19.3 nmol/liter). The concentration was associated with the number of treatments and the time from the last treatment. Modest differences were present between various antimicrobials. The authors' findings support the crucial role of gut microflora in the metabolism of lignans. Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied.
antibiotics; bacteria; biological markers; cross-sectional studies; drug therapy; intestines; lignans; metabolism
Abbreviations: BMI, body mass index; CI, confidence interval; SD, standard deviation; TR-FIA, time-resolved fluoroimmunoassay
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