Am J Epidemiol 2003; 157:25-31.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Endogenous Hormones and Carotid Atherosclerosis in Elderly Men
1 Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
2 Julius Center for Health Sciences of Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
The aging process is characterized by a number of gradual changes in circulating hormone concentrations as well as a gradual increase in the degree of atherosclerosis. The authors studied whether serum hormone levels are related to atherosclerosis of the carotid artery in independently living, elderly men. In 1996, 403 men (aged 73–94 years) were randomly selected from the general population of Zoetermeer, the Netherlands. Carotid artery intima-media thickness was determined. Serum concentrations of testosterone; estrone; estradiol; dehydroepiandrosterone and dehydroepiandrosterone sulfate; insulin-like growth factor I (IGF-I) (total and free) and its binding proteins IGFBP-1, IGFBP-2, and IGFBP-3; and leptin were measured. After the authors adjusted for age, serum testosterone, estrone, and free IGF-I were inversely related to intima-media thickness. The strength of these relations was as powerful in subjects with as in those without prevalent cardiovascular disease. Serum estradiol; dehydroepiandrosterone sulfate; total IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3; and leptin showed no association. These findings suggest that endogenous testosterone, estrone, and free IGF-I levels may play a protective role in the development of atherosclerosis in aging men.
aging; atherosclerosis; cardiovascular diseases; hormones; men
Abbreviations: Abbreviations: DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate; IGF, insulin-like growth factor; IGFBP, insulin-like growth factor binding protein; IMT, intima-media thickness; SE, standard error.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. S. Martin, A. Qasim, and M. P. Reilly Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease J. Am. Coll. Cardiol., October 7, 2008; 52(15): 1201 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Qasim, N. N. Mehta, M. G. Tadesse, M. L. Wolfe, T. Rhodes, C. Girman, and M. P. Reilly Adipokines, insulin resistance, and coronary artery calcification. J. Am. Coll. Cardiol., July 15, 2008; 52(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Brugts, A. W. van den Beld, L. J. Hofland, K. van der Wansem, P. M. van Koetsveld, J. Frystyk, S. W. J. Lamberts, and J. A. M. J. L. Janssen Low Circulating Insulin-Like Growth Factor I Bioactivity in Elderly Men Is Associated with Increased Mortality J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2515 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, A. Sciacqua, M. Perticone, I. Laino, S. Miceli, I. Care', G. Galiano Leone, F. Andreozzi, R. Maio, and G. Sesti Low-Plasma Insulin-Like Growth Factor-I Levels Are Associated with Impaired Endothelium-Dependent Vasodilatation in a Cohort of Untreated, Hypertensive Caucasian Subjects J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2806 - 2810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lehtonen, R. Huupponen, J. Tuomilehto, S. Lavonius, S. Arve, H. Isoaho, I. Huhtaniemi, and R. Tilvis Serum testosterone but not leptin predicts mortality in elderly men Age Ageing, July 1, 2008; 37(4): 461 - 464. [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Koh, S. M. Park, and M. J. Quon Leptin and Cardiovascular Disease: Response to Therapeutic Interventions Circulation, June 24, 2008; 117(25): 3238 - 3249. [Full Text] [PDF]
|
|
|
|
|
|
K.-T. Khaw, M. Dowsett, E. Folkerd, S. Bingham, N. Wareham, R. Luben, A. Welch, and N. Day Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study Circulation, December 4, 2007; 116(23): 2694 - 2701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tivesten, D. Mellstrom, H. Jutberger, B. Fagerberg, B. Lernfelt, E. Orwoll, M. K. Karlsson, O. Ljunggren, and C. Ohlsson Low Serum Testosterone and High Serum Estradiol Associate With Lower Extremity Peripheral Arterial Disease in Elderly Men: The MrOS Study in Sweden J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1070 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Kaplan, A. P. McGinn, M. N. Pollak, L. H. Kuller, H. D. Strickler, T. E. Rohan, A. R. Cappola, X. Xue, and B. M. Psaty Association of Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1), and IGFBP-3 Levels with Incident Coronary Events and Ischemic Stroke J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1319 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Thum, S. Hoeber, S. Froese, I. Klink, D. O. Stichtenoth, P. Galuppo, M. Jakob, D. Tsikas, S. D. Anker, P. A. Poole-Wilson, et al. Age-Dependent Impairment of Endothelial Progenitor Cells Is Corrected by Growth Hormone Mediated Increase of Insulin-Like Growth Factor-1 Circ. Res., February 16, 2007; 100(3): 434 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tivesten, J. Hulthe, K. Wallenfeldt, J. Wikstrand, C. Ohlsson, and B. Fagerberg Circulating Estradiol Is an Independent Predictor of Progression of Carotid Artery Intima-Media Thickness in Middle-Aged Men J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4433 - 4437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Abe, T. Matsunaga, K. Kameda, H. Tomita, T. Fujiwara, H. Ishizaka, H. Hanada, K. Fukui, I. Fukuda, T. Osanai, et al. Increased Level of Pericardial Insulin-Like Growth Factor-1 in Patients With Left Ventricular Dysfunction and Advanced Heart Failure J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1387 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bondanelli, M. R. Ambrosio, A. Onofri, A. Bergonzoni, S. Lavezzi, M. C. Zatelli, D. Valle, N. Basaglia, and E. C. degli Uberti Predictive Value of Circulating Insulin-Like Growth Factor I Levels in Ischemic Stroke Outcome J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3928 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Efstratiadis, G. Tsiaousis, V. G. Athyros, D. Karagianni, A. Pavlitou-Tsiontsi, A. Giannakou-Darda, and C. Manes Total Serum Insulin-like Growth Factor-1 and C-Reactive Protein in Metabolic Syndrome With or Without Diabetes Angiology, May 1, 2006; 57(3): 303 - 311. [Abstract] [PDF]
|
|
|
|
|
|
G. Bernini, D. Versari, A. Moretti, A. Virdis, L. Ghiadoni, M. Bardini, C. Taurino, D. Canale, S. Taddei, and A. Salvetti Vascular Reactivity in Congenital Hypogonadal Men before and after Testosterone Replacement Therapy J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1691 - 1697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Norata, G. Tibolla, P. M. Seccomandi, A. Poletti, and A. L. Catapano Dihydrotestosterone Decreases Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-Induced Inflammatory Response in Human Endothelial Cells J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 546 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kaufman and A. Vermeulen The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications Endocr. Rev., October 1, 2005; 26(6): 833 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nuver, A. J. Smit, B. H.R. Wolffenbuttel, W. J. Sluiter, H. J. Hoekstra, D. T. Sleijfer, and J. A. Gietema The Metabolic Syndrome and Disturbances in Hormone Levels in Long-Term Survivors of Disseminated Testicular Cancer J. Clin. Oncol., June 1, 2005; 23(16): 3718 - 3725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Makinen, M. J. Jarvisalo, P. Pollanen, A. Perheentupa, K. Irjala, M. Koskenvuo, J. Makinen, I. Huhtaniemi, and O. T. Raitakari Increased Carotid Atherosclerosis in Andropausal Middle-Aged Men J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1603 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Barrett-Connor Andropause and Intima Media Thickness J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1609 - 1610. [Full Text] [PDF]
|
|
|
|
|
|
G. B. Phillips Is Atherosclerotic Cardiovascular Disease an Endocrinological Disorder? The Estrogen-Androgen Paradox J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2708 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A M Smith, K M English, C J Malkin, R D Jones, T H Jones, and K S Channer Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina Eur. J. Endocrinol., February 1, 2005; 152(2): 285 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Peeters, A. W. van den Beld, H. van Toor, A. G. Uitterlinden, J. A. M. J. L. Janssen, S. W. J. Lamberts, and T. J. Visser A Polymorphism in Type I Deiodinase Is Associated with Circulating Free Insulin-Like Growth Factor I Levels and Body Composition in Humans J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 256 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Conti, C. Carrozza, E. Capoluongo, M. Volpe, F. Crea, C. Zuppi, and F. Andreotti Insulin-Like Growth Factor-1 as a Vascular Protective Factor Circulation, October 12, 2004; 110(15): 2260 - 2265. [Full Text] [PDF]
|
|
|
|
|
|
M. P. Reilly, N. Iqbal, M. Schutta, M. L. Wolfe, M. Scally, A. R. Localio, D. J. Rader, and S. E. Kimmel Plasma Leptin Levels Are Associated with Coronary Atherosclerosis in Type 2 Diabetes J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3872 - 3878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C J Malkin, P J Pugh, P D Morris, K E Kerry, R D Jones, T H Jones, and K S Channer Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life Heart, August 1, 2004; 90(8): 871 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muller, A. W. van den Beld, M. L. Bots, D. E. Grobbee, S. W.J. Lamberts, and Y. T. van der Schouw Endogenous Sex Hormones and Progression of Carotid Atherosclerosis in Elderly Men Circulation, May 4, 2004; 109(17): 2074 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Littleton-Kearney and P. D. Hurn Testosterone as a Modulator of Vascular Behavior Biol Res Nurs, April 1, 2004; 5(4): 276 - 285. [Abstract] [PDF]
|
|
|
|
|
|
J. Hsia, M. H. Criqui, R. J. Rodabough, R. D. Langer, H. E. Resnick, L. S. Phillips, M. Allison, D. E. Bonds, K. Masaki, P. Caralis, et al. Estrogen Plus Progestin and the Risk of Peripheral Arterial Disease: The Women's Health Initiative Circulation, February 10, 2004; 109(5): 620 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Laughlin, E. Barrett-Connor, M. H. Criqui, and D. Kritz-Silverstein The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 114 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muller, Y. T. van der Schouw, J. H. H. Thijssen, and D. E. Grobbee Endogenous Sex Hormones and Cardiovascular Disease in Men J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5076 - 5086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Morley The Need for a Men's Health Initiative J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M614 - 617. [Full Text] [PDF]
|
|
|
|
|
|
P. Y. Liu, A. K. Death, and D. J. Handelsman Androgens and Cardiovascular Disease Endocr. Rev., June 1, 2003; 24(3): 313 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Twickler, M. J. M. Cramer, G. M. Dallinga-Thie, M. J. Chapman, D. W. Erkelens, and H. P. F. Koppeschaar Adult-Onset Growth Hormone Deficiency: Relation of Postprandial Dyslipidemia to Premature Atherosclerosis J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2479 - 2488. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mahmud and M. L. Vance Human Growth Hormone and Aging N. Engl. J. Med., May 29, 2003; 348(22): 2256 - 2257. [Full Text] [PDF]
|
|